Nearly every runner is available at double-figure odds and there will be plenty of each-way money flying around for the Newmarket race, with Tiger Cliff among the favourites at odds of 8/1 with bet365.
The Lady Cecil horse is carrying top weight although the four-year-old has claimed victories at Newmarket and York this season, with a fine run at Royal Ascot which saw the runner finish second in the Ascot Stakes.
Lady Cecil is hopeful of a big run, with her late husband having won the Newmarket handicap in 1971 with Orosio.
“Henry has won it once. We’d settle for winning it once too. But we’re really lucky because we’ve won races at Ascot, Goodwood, York. But to have a winner at Newmarket, which is our home track, would be fantastic,” Lady Cecil told BBC Look East.
There are plenty of runners offering stiff competition, with Pallasator among them and many firms are going 7/1 about another four-year-old, although the Sir Mark Prescott charge has only run once this term, finishing third on his seasonal debut.
“We wanted to start him off in the Northumberland Plate, but we had a hold-up and we were eight weeks behind with him,” Prescott said.
“Pallasator has a very, very good chance if he stays. He does get himself into quite a stew before the race so he will go down to the start with a pony.
“You have to go the full two and a quarter miles down to the start, so for a horse who gets on edge, it’s a long way to go.
“He always works well and is not a slow stayer but he would be vulnerable to those who really stay and grind it out.”
Oriental Fox is a 9/1 chance and claimed victory in the Cesarewitch Trial last month to cement his credentials for the race proper on Saturday, while Smoky Hill and Domination are currently trading at 10/1.
Nicky Henderson is predominantly known as a National Hunt trainer although he has Lieutenant Miller and French recruit Earth Amber in the race, with the former having been placed in the Ascot and Goodwood takes.
Henderson said: “He had a couple of hard races there but he is a toughened performer and we have given him a little freshen up.
“He has gone up in the weights without winning a race but that is just a fact of life in racing and fast ground definitely suits him.
“Earth Amber might prefer the ground a bit easier, a drop of rain would help her. She was quite fit when she came over from France where she had just finished second to a horse called Les Beaufs, who went on to win a Group One, and we then decided to shelve plans to run her over hurdles last winter.
“I’d like to stick them both in Earth Amber’s stall if we were allowed.”