Toure was injured during extra-time of Liverpool’s League Cup win against Notts County, much to the chagrin of club captain Steven Gerrard, who was dismayed that his team couldn’t see off the League One side in normal time.
However, Martin Skrtel should be fit for this huge Premier League clash and perhaps the Slovakian can resurrect his Anfield career by helping his team beat the Red Devils and continue their 100% start to the season.
The bookies make Liverpool favourites to win this match, with bet365 going 13/8 that they open up a five-point gap over their arch-rivals, with Brendan Rodgers sweating over the fitness of Joe Allen and Aly Cissokho following injuries sustained during the week.
However, Philippe Coutinho was used sparingly and Iago Aspas remained on the bench, with these two players potentially holding the key to the home side unlocking the Manchester United defence which looked rock solid against Swansea and Chelsea.
Daniel Sturridge continued his excellent start to the season by scoring twice against the Magpies and could he score the only goal of the game for the third time running in a Liverpool shirt?
Many are describing the former Chelsea forward as the best striker that England have at the moment and bet365 offer 6/1 about him breaking the deadlock in this game, while the 1-0 scorecast featuring Sturridge is generally 25/1 and could be a decent shout.
David Moyes will certainly want to avoid defeat in this match following the draw with Chelsea and the Scot might be reluctant to field an attacking line-up, although it appears as though Wayne Rooney is going to stay at Old Trafford after a summer of discontent.
Rooney was the best player on the pitch against Chelsea and might well play in the hole behind Robin van Persie, with Coral offering odds of 19/10 about an away win at Anfield, with the Red Devils having claimed a 4-1 victory at Swansea in their first match of the season.
BetVictor offer a best price 12/5 about the game ending all square and perhaps that represents the best value considering we might see a cagey encounter, with a draw not being a bad result for Rodgers’ team considering they have opened the campaign with two wins.
Coral go even money that we see less than 2.5 Goals at Anfield, with Liverpool having kept two clean sheets in the Premier League and their opponents having shipped just one in their two matches. However, that man RVP is capable of scoring from a half-chance that comes his way.
The Dutchman was lethal at the Liberty Stadium and can be backed at 19/4 with BetVictor to score the first goal, with Rooney a 15/2 poke and it would be a perfect way to thanks the United fans who have backed him despite the forward angling for a move away from Old Trafford.