This was a fixture Liverpool won in convincing fashion last season, with the Reds running riot when claiming a 5-0 victory although the chief architect behind that win is now waiting for his turn at Barcelona.
Brendan Rodgers has turned to Mario Balotelli in the hope of compensating for the loss of Luis Suarez, with some claiming it’s a case of “out of the frying pan, into the fire” by signing a controversial forward who was once described by Jose Mourinho as “unmanageable”.
After Liverpool’s 3-1 reverse at the Etihad Stadium on Monday, the bookies are happy to take on the Merseyside team despite slamming Tottenham home and away last term, with Sky Bet offering odds of 7/4 that the Reds win.
The visitors actually looked quite bright in the opening exchanges of the match against Manchester City, with Daniel Sturridge getting the better of Vincent Kompany and also setting up his team’s consolation goal.
While Balotelli is almost certain to be on the bench for this game, Sturridge is the main man for Liverpool in attack and the England forward can be backed at 13/2 with Coral to break the deadlock in this game.
Rodgers has been impressed by Balotelli, telling the club’s official website: "I think by the weekend [he'll be ready to feature].
"He's been into pre-season and he's played three 45-minute games. He might not be up to full match speed, but he's looking fit.
"We've done some analysis on him. The medical and sports science team have worked with him already and he's in very, very good condition.
"He's in to work and he'll be available for the squad for the weekend."
Nevertheless, it’s two wins from two for Tottenham who followed up a narrow win at Upton Park with four goals against Queens Park Rangers last Sunday.
Mauricio Pochettino has not done a great deal of business this summer and aims to get the best out of players such as Nacer Chadli and Erik Lamela, while Christian Eriksen is also a first-team regular at the moment.
Spurs are a 17/10 chance with BetVictor to win the game and they will be confident of getting among the goals again, with the best bet potentially backing both teams to score.
With Raheem Sterling probing away at a Tottenham defence yet to concede in the Premier League, all signs point to this happening with odds of 11/20 on offer at Ladbrokes.