The Australian Open, which gets underway next week, is the Grand Slam curtain-raiser.
Novak Djokovic is bidding to claim a record-extending eighth title in Melbourne, but there will be plenty of fascinating storylines during the tournament.
Djokovic, fresh from his exploits with Serbia over Spain in the ATP Cup final, is the short-priced favourite with a best price of 13/10 and a general price of 6/5.
While Nadal is world No 1, he has only won the tournament once and Djokovic is the immovable object at Melbourne Park.
Djokovic has won nine of their last 10 meetings without dropping a set. In last year's Australian Open final, the 32-year-old underlined his dominance as 34 winners flew off his racquet and he converted five of his eight break-point opportunities.
Djokovic is one of the greatest returners ever and he has few obvious flaws. The courts play quick Down Under and it is tailor-made for his game.
He has an unshakeable belief and his court coverage is superior to that of his rivals. Yet what is surprising, is that he doesn't think he is a shoo-in to win the Australian Open.
Speaking after the ATP Cup win over Spain, he said: "I don't think there are really clear favourites. You have obviously (Roger) Federer, Nadal, myself because of the experience and everything and the rankings that we get to be probably named the top three favourites."
Medvedev Trending Nicely
Already a two-time Masters champion, Daniil Medvedev (8/1) sent shockwaves through the game in 2019.
In reaching six finals on the trot, the Russian has shown he has the tools to compete with the best. He resembles something of a wall on court as he returns everything with purchase and he is now up to fourth in the world rankings.
He was unlucky against Rafael Nadal in the US Open final, but playing the 'Big Three' over five sets as opposed to three is a different beast.
Currently, he is a shorter price in the outright market than seven-times champion Roger Federer (11/1), but the Swiss legend hasn't played since November and as the game's eldest statesman, he is trying to prolong his career and add a 21st Major to his cabinet.
Can Tsitsipas Break London Curse?
Stefanos Tsitsipas – who is tucked in behind Federer in the Australian Open odds at a best price of 12/1 – will come under more scrutiny this season.
The Greek has made rapid progress on the Tour and he has a tough ask trying to thwart the 'Big Three' and their stranglehold on tennis' big prizes as they have won each of the past 12 Majors.
Tsitsipas has a fabulous all-round game and one that he seems to have modelled on that of Federer.
While winning the World Tour Finals last year was a statement of intent, for other champions such as Alexander Zverev (50/1) and Grigor Dimitrov (80/1), it has been a curse as they haven't cracked the code for winning Majors, so it will be interesting to see how Tsitsipas handles the pressure in his pursuit of Grand Slam success.